Achyrocline satureioides herb is known as Marcela in Brazil, benefit of the plant
March 1 2017

Aerial parts of Achyrocline satureioides are used in folk medicine as infusions or decoctions for the management of several diseases including gastrointestinal and liver disorders and also as an anti-inflammatory herb. Ethanol extract of the aerial parts of Achyrocline satureioides have a significant, dose dependent, relaxant effect on the smooth muscle of corpus cavernosum.
Achyrocline satureioides is the botanical name for the herb in Brazil called marcela.

As of 2017, we did not find clinical published studies with Achyrocline satureioides herb in humans.

Chemical composition of achyrocline satureioides herb
The aerial parts of this herb have flavonoids such as quercetin, luteolin and 3-O-methylquercetin, caffeoyl derivatives such as caffeic acid, and a prenylated dibenzofuran called achyrofuran. The essential oils of the aerial parts of achyrocline satureioides have monoterpene and sesquiterpene hydrocarbons.

Sex boosting herbs available over the counter
These aphrodisiacs herbal products include Maca Extract, tongkat ali, butea superba, cnidium monnieris, Tribulus Terrestris Extract, mucuna pruriens, horny goat weed, avena sativa, LJ100, muira puama, catuaba, and yohimbe bark extract.

Safety, side effects
Food Chem Toxicol. 2013. Evaluation of the cytotoxicity, genotoxicity and apoptotic induction of an aqueous extract of Achyrocline satureioides. This  herb is widely consumed as infusion or aperitif and shows important therapeutic properties. Previously, we reported absence of genotoxicity of cold aqueous extract (CAE) of A. satureioides by Allium test. However, one test cannot predict the genotoxic effects of a substance. Thus, the aim of this work was to investigate cytotoxicity, genotoxicity and apoptotic ability of CAE of A. satureioides. In addition, CAE was chemically characterized. The cytotoxicity was evaluated by Trypan blue and MTT assays. The apoptotic capacity was evaluated by Hoechst staining and DNA fragmentation-analysis. The genotoxicity was studied by comet assay (CA) and micronucleus test. The identification and quantification of flavonoids were performed. The cytotoxicity studies indicated low toxicity of CAE. In addition, CAE did not induce apoptotic effects on human PBMCs. CAE did not show genotoxicity in vitro against Vero cells. CAE did not induce in vivo genotoxic effects, but it showed at high concentrations cytotoxicity by micronucleus assay. Achyrocline satureioides presented flavonoids such as quercetin, 3-O-methylquercetin and luteolin. In conclusion, A. satureioides at popularly concentrations used, in aperitif or infusion, can be consumed safely because did not show any cytotoxic or genotoxic effects.

Research review
Differentiation induced by Achyrocline satureioides infusion in PC12 cells.
Phytother Research. 2009; Blasina MF, Vaamonde L, Morquio A, Echeverry C, Arredondo F, Dajas F. Department of Neurochemistry, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.
Epidemiological studies have shown that flavonoid-rich plants induce beneficial health effects that are likely beyond their potent antioxidant capacity. Thus, the mechanisms by which Achyrocline satureioides, a popular South American medicinal plant, protects cells and neurons in culture, are still unclear. In this sense, a recently described trophic capacity for flavonoids, similar to that evoked by growth factors, could be one of the mechanisms involved in  cellular protection. Since this trophic activity causes differentiation of PC12 cells, the cell differentiation capacity of this herb and some of its flavonoids were evaluated. PC12 cells were treated with Achyrocline satureioides infusion (10 or 20 microg/mL of total polyphenols), quercetin (Q), luteolin (L), Q + L or nerve growth factor (NGF) for 3 days. Four morphological parameters (percentage of cells with neurites longer than one cell body diameter, percentage of cells with neurites, average number of neurites per cell and percentage of fusiform cells) were explored. The AS infusion showed differentiation capacity on all parameters with similar potency when compared with NGF. Besides, Achyrocline satureioides was more potent than some of its constituent flavonoids: Q, L or their combination.

Achyrocline species
alata
satureioides
tomentosa